![]() ![]() While a previous study demonstrated that CR led to browning of white adipose tissue, another study indicated that CR during pregnancy diminished thermogenic capacity in the offspring, including impaired BAT sympathetic innervation and thyroid hormone signaling. Given these findings, it is clear that adaptation to CR leads to progressive recruitment of metabolic tissues, but effects on BAT are still poorly explored. It is also evident that CR can improve liver lipid metabolism and reduce systemic inflammation. For example, short-term CR feeding enhances skeletal muscle stem cell function, mitochondrial function and muscle repair and, eventually, improves muscle insulin sensitivity. Though the precise mechanisms of reaction to CR are still not fully defined, the metabolic benefits have been studied in different tissues. These data comprise an extensive resource for the study of thermogenic tissue molecular responses to CR and/or EX in a healthy state.ĬR, a classical example of negative energy balance, extends healthy lifespan from yeast to mammals. NicheNet analysis, exploring potential inter-organ communication, indicated that BAT and skeletal muscle could mutually regulate their fatty acid metabolism and thermogenesis through ligands and receptors. Deconvolution analysis showed differences in the subpopulations of myogenic cells, mesothelial cells and endogenic cells in BAT and in the subpopulations of satellite cells, immune cells and endothelial cells in skeletal muscle as a result of CR or EX. Consistent with this, CR induced alterations in the expression of genes encoding adipokines and myokines in BAT and skeletal muscle, respectively. We found transcriptional reprogramming of BAT and skeletal muscle as a result of CR but little from EX. ![]() Here, we undertook detailed transcriptional profiling of these two thermogenic tissues from mice treated subjected to CR and/or EX. Brown adipose tissue (BAT) and skeletal muscle are two important organs for the generation of heat. Calorie restriction (CR) and exercise training (EX) are two critical lifestyle interventions for the prevention and treatment of metabolic diseases, such as obesity and diabetes. ![]()
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